Bioorganic and Medicinal Chemistry Letters p. 755 - 758 (1999)
Update date:2022-07-30
Topics:
Naylor, Elizabeth M.
Parmee, Emma R.
Colandrea, Vincent J.
Perkins, Leroy
Brockunier, Linda
Candelore, Mari R.
Cascieri, Margaret A.
Colwell Jr., Lawrence F.
Deng, Liping
Feeney, William P.
Forrest, Michael J.
Hom, Gary J.
MacIntyre, D. Euan
Strader, Catherine D.
Tota, Laurie
Wang, Pei-Ran
Wyvratt, Matthew J.
Fisher, Michael H.
Weber, Ann E.
The cyclopentylpropylimidazolidinone L-766,892 is a potent β3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the β1 and β2 ARs, respectively. In anesthetized rhesus monkeys, L-766,892 elicited dose-dependent hyperglycerolemia (ED50 0.1 mg/kg) with minimal effects on heart rate.
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