Human β3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides

Article abstract of DOI:10.1016/S0960-894X(99)00072-4

The cyclopentylpropylimidazolidinone L-766,892 is a potent β₃ AR agonist (EC₅₀ 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the β₁ and β₂ ARs, respectively. In anesthetized rhesus monkeys, L-766,892 elicited dose-dependent hyperglycerolemia (ED₅₀ 0.1 mg/kg) with minimal effects on heart rate.