An extremely high insulin-mimetic activity of bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex

Article abstract of DOI:10.1246/cl.2002.114

Vanadyl and zinc(II) complexes with VO(O₂S₂) and Zn(O₂S₂) coordination mode, respectively, were synthesized. Among them, bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato)zinc(II) complex exhibited an extremely high insulin-mimetic activity (IC₅₀ = 0.04 mM when IC₅₀ value of a positive control, VOSO₄ was estimated to be 1.0 mM) compared to vanadyl and zinc(II) complexes reported previously.