Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds.

DOI: 10.1016/S0960-894X(97)00346-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1957 - 1962 (1997)

Update date:2022-08-05

Topics:

Authors:

Horwell Horwell

Kneen Kneen

Pritchard

Ratcliffe

Roberts Roberts

Suman-Chauhan

Steiner Steiner

Betche Betche

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Article abstract of DOI:10.1016/S0960-894X(97)00346-6

A targeted set of 256 aromatic α-amino acid derivatives is described to provide new lead compounds for biological screening. The utility is exemplified by identification of ligands for the human neuromedin B (hNMB) receptor, such as compound 3 (Ki hNMB 37nM).

Full text of DOI:10.1016/S0960-894X(97)00346-6

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