Synthetic Communications p. 137 - 147 (2007)
Update date:2022-08-03
Topics:
Zhao, Zhi-Gang
Wang, Zhong-Xia
Reaction of pyrazoles with N-halosuccinimides (NXS, X=Br, Cl) in either CCl4 or water gave 4-halopyrazoles in excellent yields. The reaction was carried out under mild conditions and did not require any catalysts or special precautions. The reaction provides an efficient method for 4-C halogenation of pyrazoles. Copyright Taylor & Francis Group, LLC.
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