Unexpected rearrangement in the Heck cyclization of positional isomers of chiral 2,3-disubstituted perhydro-1,3-benzoxazines

DOI: 10.1055/s-2002-19756

Source and publish data:

Synlett p. 259 - 262 (2002)

Update date:2022-07-30

Topics:

Authors:

Pedrosa, Rafael

Andrés, Celia

Iglesias, Jesús M.

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Article abstract of DOI:10.1055/s-2002-19756

The intramolecular Heck cyclization on 2,3-disubstituted perhydro-1,3-benzoxazines, derived from (-)-8-amino menthol, easily proceeds at reflux of acetonitrile or DMF. The behavior of positional isomers was quite different. Reaction of 2-aryl-3-allyl perh

Full text of DOI:10.1055/s-2002-19756

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