Bioorganic and Medicinal Chemistry Letters p. 2261 - 2267 (2003)
Update date:2022-07-30
Topics:
Engler, Thomas A.
Furness, Kelly
Malhotra, Sushant
Sanchez-Martinez, Concha
Shih, Chuan
Xie, Walter
Zhu, Guoxin
Zhou, Xun
Conner, Scott
Faul, Margaret M.
Sullivan, Kevin A.
Kolis, Stanley P.
Brooks, Harold B.
Patel, Bharvin
Schultz, Richard M.
DeHahn, Tammy B.
Kirmani, Kashif
Spencer, Charles D.
Watkins, Scott A.
Considine, Eileen L.
Dempsey, Jack A.
Ogg, Catherine A.
Stamm, Nancy B.
Anderson, Bryan D.
Campbell, Robert M.
Vasudevan, Vasu
Lytle, Michelle L.
The synthesis and CDK inhibitory properties of a series of indolo[6,7-a]pyrrolo[3,4-c]carbazoles is reported. In addition to their potent CDK activity, the compounds display antiproliferative activity against two human cancer cell lines. These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4.
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