Bioorganic and Medicinal Chemistry Letters p. 4212 - 4216 (2005)
Update date:2022-07-29
Topics:
Sparey, Tim
Beher, Dirk
Best, Jonathan
Biba, Mirlinda
Castro, Jose L.
Clarke, Earl
Hannam, Joanne
Harrison, Timothy
Lewis, Huw
Madin, Andrew
Shearman, Mark
Sohal, Bindi
Tsou, Nancy
Welch, Christopher
Wrigley, Jonathan
A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. Chemistries were developed which allowed surveys of N-alkyl groups and amines resulting in the identification of N-trifluoroethyl- substituted cyclic sulfamides with good in vitro and in vivo γ-secretase activity. One compound with subnanomolar activity elicited a reduction in brain Aβ40 after oral dosing in APP-YAC mice.
View MoreKangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Ningbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
lianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Suzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Doi:10.1016/S0040-4039(01)02128-1
(2002)Doi:10.1246/bcsj.54.3743
(1981)Doi:10.1139/v57-064
(1957)Doi:10.1016/j.bioorg.2020.104148
(2020)Doi:10.1021/jo00240a015
(1988)Doi:10.1002/ejoc.201700607
(2017)