Carbohydrate Research (2019)
Update date:2022-08-04
Topics:
Cheng, Janice M.H.
Chee, Stephanie H.
D?len, Yusuf
Verdoes, Martijn
Timmer, Mattie S.M.
Stocker, Bridget L.
Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N-hydroxysuccinimidyl ester to facilitate conjugation and purification of the target glycolipid. For the preparation of the core of the glycolipid, the solubility of the lipid acceptor proved to be critical. The ability of BODIPY-αGalCer 3 to activate invariant natural killer cells was then demonstrated in vitro.
View MoreChongqing Acme Tech. Co., Ltd.
Contact:+86-23-89118971
Address:2501 Huachuang Bldg., No.10 Red-yellow Road, Jiangbei
Contact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Beijing Top Science biological technology co., LTD
Contact:+86-13439059536
Address:15-1705 jre three mile, Beijing 100000,CHINA
Chongqing Werlchem Fine Chemical Co. Ltd
Contact:+86-23-67521957
Address:NO.15,Fortune Road,Yubei District,401121,Chongqing,China
Xinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
Doi:10.1021/jo00085a033
(1994)Doi:10.1039/P19730000823
(1973)Doi:10.1039/c7nj04386d
(2018)Doi:10.1016/0040-4020(73)80122-X
(1973)Doi:10.1021/jo300543n
(2012)Doi:10.1007/s00706-011-0669-1
(2012)