Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors

Article abstract of DOI:10.1016/j.bmcl.2011.08.053

A group of celecoxib analogs having a SO₂NH₂ (9a-f), or SO₂Me (12a-f), COX-2 pharmacophore at the para-position of the N-1 phenyl ring in conjunction with a C-5 phenyl ring having a variety of substituents (4-, 3-, 2-OAc;