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ChemComm
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COMMUNICATION
Journal Name
Lett. 2020, 22, 5, 1760.
useful for late-stage functionalization of hydrocarbons in
medicinal chemistry where urethanes are widespread.
4
5
6
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Cu(I)
X
L
NHCO2R'
R2
N F
Cu(I)XL
Ar
R'
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III
H
R
R
Ar
R'
N
I
B
X(F)
7
8
R'O2CHN
F
X
Cu(III)
L
Cu(II)
L
Ar
R'
R2NH
Ar
R'
C
E
A
X(F)
R'
F or X
III
IV
Ar
H2NCO2R'
Cu(III)
pathway
9
- Cu(I)L
F
Cu(III)
O
F
Ar
R'
F- or X-
IV
L
X
radical-polar
crossover
pathway
H2
N
OR'
Ar
R'
II
D
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Figure 2 Proposed reaction mechanism for the benzylic C-H amination.
SL thanks the Chinese Scholarship Council (CSC) for a PhD
grant. We are grateful to the University of Bordeaux (UBx) and
to the CNRS for financial support. Dr. C. Absalon (Cesamo, Ubx)
is gratefully acknowledged for GC-MS experiments.
Conflicts of interest
“There are no conflicts to declare”.
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