Bioorganic and Medicinal Chemistry Letters p. 4623 - 4626 (2004)
Update date:2022-08-02
Topics:
Lorthiois, Edwige
Bernardelli, Patrick
Vergne, Fabrice
Oliveira, Chrystelle
Mafroud, Abdel-Kader
Proust, Emmanuelle
Heuze, Lamia
Moreau, Fran?ois
Idrissi, Moulay
Tertre, Anita
Bertin, Bernadette
Coupe, Magali
Wrigglesworth, Roger
Descours, Arnaud
Soulard, Patricia
Berna, Patrick
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
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