Bioorganic and medicinal chemistry letters p. 1663 - 1666 (2002)
Update date:2022-08-03
Topics:
Buynak, John D
Vogeti, Lakshminarayana
Doppalapudi, Venkata Ramana
Solomon, George Martin
Chen, Hansong
New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.
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