Palladium-catalyzed formation of cyclic ethers - Regio-, stereo- and enantioselectivity of the reaction

Article abstract of DOI:10.1002/ejoc.200601019

An efficient and stereoselective synthesis of 3-alkyl-3-hydroxymethyl-5- vinyltetrahydrofurans is described by the Pd⁰-catalyzed cyclization of the methyl carbonates of ω,ω-bis(hydroxymethyl)-α,β- unsaturated alcohols. The use of chiral ligands