Synthesis of Inhibitors of Adenosine Deaminase. A Total Synthesis of erythro-3-(Adenin-9-yl)-2-nonanol and Its Isomers from Chiral Precursors

Article abstract of DOI:10.1021/jo00132a039

The synthesis of both isomers of EHNA² ("erythrohydroxynonyladenine") from D- and L-rhamnose is described.The key intermediates, (R)- and (S)-2-(benzyloxy)propanal, derived respectively from 5-O-benzyl-D- and -L-rhamnitol, were each condensed w