Journal of the American Chemical Society p. 4567 - 4572 (1994)
Update date:2022-09-26
Topics: Nuclear magnetic resonance (NMR) spectroscopy binding affinity X-ray crystallography Fluorescence Spectroscopy Complexation Metal ions Saccharides
Deng, Gang
James, Tony D.
Shinkai, Seiji
A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are succesfully coupled in an allosteric system.The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD).Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity.This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.
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