
Journal of Fluorine Chemistry p. 71 - 75 (1996)
Update date:2022-09-26
Topics:
Filler, Robert
Kong, Zhengrong
Zhang, Zhaoxu
Sinha, Arun Kr.
Li, Xiaofang
2,4,6-Tris(trifluoromethyl)phenyllithium (1) reacts with acetaldehyde and acrolein to give the corresponding alcohols 5 and 8. Oxidation of the alcohols with the CrO3-pyridine complex affords the acetophenone 3 and the vinyl ketone 7 respectively. The reactions of 1 with trifluoroacetic anhydride and trimethylsilyl trifluoroacetate give low to moderate yields of the trifluoroacetophenone 6.
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