The 2,4,6-tris(trifluoromethyl)phenyl group: Methyl and vinyl ketones and related chemistry

Article abstract of DOI:10.1016/S0022-1139(96)03498-7

2,4,6-Tris(trifluoromethyl)phenyllithium (1) reacts with acetaldehyde and acrolein to give the corresponding alcohols 5 and 8. Oxidation of the alcohols with the CrO₃-pyridine complex affords the acetophenone 3 and the vinyl ketone 7 respectively. The reactions of 1 with trifluoroacetic anhydride and trimethylsilyl trifluoroacetate give low to moderate yields of the trifluoroacetophenone 6.