Total synthesis of desferrisalmycin B

DOI: 10.1021/ja028386w

Source and publish data:

Journal of the American Chemical Society p. 15001 - 15005 (2002)

Update date:2022-08-02

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Authors:

Dong, Li

Roosenberg II, John M.

Miller, Marvin J.

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Article abstract of DOI:10.1021/ja028386w

The first total synthesis of a naturally occurring siderophore antibiotic, desferrisalmycin B, is described, and the configuration of the unknown stereocenter is assigned. The synthesis features a synthetic strategy of constructing the novel amino-heptopyranoside component by stereoselective dihydroxylation followed by a Bose-modified Mitsunobu reaction. Through this convergent approach, other members of salmycins should also be synthetically accessible.

Full text of DOI:10.1021/ja028386w

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