Journal of Medicinal Chemistry p. 2072 - 2079 (2005)
Update date:2022-08-03
Topics:
Guillemont, Jerome
Pasquier, Elisabeth
Palandjian, Patrice
Vernier, Daniel
Gaurrand, Sandrine
Lewi, Paul J.
Heeres, Jan
De Jonge, Marc R.
Koymans, Lucien M. H.
Daeyaert, Frits F. D.
Vinkers, Maarten H.
Arnold, Eddy
Das, Kalyan
Pauwels, Rudi
Andries, Koen
De Béthune, Marie-Pierre
Bettens, Eva
Hertogs, Kurt
Wigerinck, Piet
Timmerman, Philip
Janssen, Paul A. J.
This paper reports the synthesis and the antiviral properties of new diarylpyrimidine (DAPY) compounds as nonnucleoside reverse transcriptase inhibitors (NNRTIs). The synthesis program around this new DAPY series was further optimized to produce compounds displaying improved activity against a panel of eight clinically relevant single and double mutant strains of human immunodeficiency virus type 1 (HIV-1).
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Doi:10.1248/cpb1953.1.230
(1953)Doi:10.1055/s-2006-949639
(2006)Doi:10.1021/jm020441o
(2003)Doi:10.1002/jhet.5570390518
(2002)Doi:10.1016/j.tet.2011.10.093
(2012)Doi:10.1002/hlca.19540370128
(1954)
