Total synthesis of (-)-aspidospermine via diastereoselective ring-closing olefin metathesis

Article abstract of DOI:10.1021/ol034020s

(Matrix presented) An enantiocontrolled total synthesis of (-)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis.