Solid-phase synthesis of carbohydrate and phosphodiester modified 2'-5' oligoadenylate analogs

Article abstract of DOI:10.1016/S0960-894X(96)00549-5

A series of 2'-5' oligoadenylate analogs containing internucleotide and ribose modifications were prepared by solid-phase methods as potential interferon mimetics. All syntheses were carried out using automated methodologies with precursors that allow for the generation of multiple combinations of modification.