An efficient method for the stereoselective synthesis of cis-3-substituted prolines: Conformationally constrained α-amino acids

Article abstract of DOI:10.1016/S0040-4020(02)01405-9

An efficient synthesis of enantiomerically pure cis-3-substituted prolines is reported. Key steps involve the stereoselective organocuprate addition to the (E)-α,β-unsaturated ester 1, obtained from the Garner's aldehyde, and expedient oxidation-cyclizati