ACS Medicinal Chemistry Letters
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proteinꢀcoupled receptor 120ꢀselective agonists derived from
Corresponding Author
PPARγ agonists. J. Med. Chem. 2008, 51, 7640.
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J.; Pediani, J. D.; Christiansen, E.; Heathcote, H.; Tobin, A. B.;
Ulven, T.; Milligan, G. The Pharmacology of TUGꢀ891, a poꢀ
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16. Azevedo, C.M.G.; Watterson, K.R.; Wargent, E.T.; Hansen,
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zuki, T.; Wang, N.; Truong, Q.; Gilbert, E.; Zhou, D.; Verras,
A.; Kirkland, M.; Pachanski, M.; Powles, M.; Yin, W.; Ujjainꢀ
walla, F.; Venkatraman, S.; Edmondson, S. D. Discovery of
chromane propionic acid analogues as selective agonists of
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18. Cox, J. M.; Chu, H. D.; Chelliah, M. V.; Debenham, J. S.; Eaꢀ
gen, K.; Lan, P.; Lombardo, M.; London, C.; Plotkin, M. A.;
Shah, U.; Sun, Z.; Vaccaro, H. M.; Venkatraman, S.; Suzuki,
T.; Wang, N.; Ashley, E. R.; Crespo, A.; Madeira, M.; Leung,
D. H.; Alleyne, C.; Ogawa, A. M.; Souza, S.; Thomasꢀ
Fowlkes, B.; Di Salvo, J.; Weinglass, A.; Kirkland, M.; Paꢀ
chanski, M.; Powles, M.; Tozzo, E.; Akiyama, T. E.; Ujjainꢀ
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M.; Finley, M. F.; Johnson, E.; Roussel, T.; Uebele, V. N.;
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*Tel: 215ꢀ628ꢀ7877. Fax: 215ꢀ540ꢀ4612. Eꢀmail:
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
We thank LG Biology, CoE for Cardiovascular Safety Research,
ADME/PK at JRD for technical assistance.
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