Journal of Medicinal Chemistry p. 624 - 630 (1974)
Update date:2022-08-05
Topics:
Tinney
Sanchez
Nogas
A series of 2,3 dihydro 1H thieno[2,3 e][1,4]diazepines was synthesized and evaluated for CNS activity. A new antianxiety screen for benzodiazepine like drugs was used along with the standard anticonvulsant test. Structure activity relationships are discussed. One compound, 1,3,6,7,8,9 hexahydro 5 phenyl 2H [1]benzothieno[2,3 e][1,4]diazepin 2 one monosulfate (CI 718), is undergoing clinical studies in man.
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Doi:10.1002/jhet.5570110204
(1974)Doi:10.1016/S0040-4039(01)82472-2
(1974)Doi:10.1080/00397910801929341
(2008)Doi:10.1021/ja01548a041
(1958)Doi:10.1002/jlcr.2590100107
(1974)Doi:10.1016/S0040-4039(01)82243-7
(1974)