Synthesis and absolute configuration of (-)-subersic acid, a sponge-derived, terpenoidal inhibitor of human 15-lipoxygenase

Article abstract of DOI:10.1002/ejoc.200390128

(-)-Subersic acid (1), a new derivative of p-hydroxybenzoic acid in which the m-position is substituted with a bicyclic diterpenoid was synthesized from (S)-3-hydroxy-2,2-dimethylcyclohexanone and p-hydroxybenzoic acid. The stereochemistry of this sponge-