
Tetrahedron Asymmetry p. 287 - 294 (1995)
Update date:2022-09-26
Topics:
Falorni. Massimo
Conti, Sandra
Giacomelli, Giampaolo
Cossu, Sergio
Soccolini, Francesco
A very simple procedure for the preparation of chiral optically active N-protected-4-carboxy-1,3-oxazolidine (4-oxaproline) derivatives starting from serine and threonine is described which avoids the use of toxic solvents or reagents.Elaboration of these compounds allows significant improvement in the handling of serine and threonine during the multigram preparation of oligopeptide structures and affords versatile chiral building blocks for the organic synthesis.
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