Tetrahedron Letters p. 4397 - 4398 (1993)
Update date:2022-08-05
Topics:
Balazs, Mihaly
Szantay, Csaba
Boelcskei, Hedvig
Szantay, Csaba
While investigating the ferric chloride mediated coupling of catharanthine (1) with vindoline (3) and their derivatives (2, 4), the borane complexes of 15',20'-anhydrovinblastine (AVLB), 20'-deethyl-AVLB and N-demethyl-AVLB (9, 10, 11) have been synthesized.The corresponding bases (6, 7 and 8) have also been obtained in high yield. Key Words: Anhydrovinblastine; 20'-deethyl-AVLB; N-demethyl-AVLB; borane complexes; FeCl3 coupling.
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