Tetrahedron Letters p. 1564 - 1567 (2018)
Update date:2022-08-03
Topics: Synthesis Chiral Propargylation Asymmetric Lactamization Cascade Isoindolinones
Meng, Jiao-Long
Jiao, Tang-Qian
Chen, Ya-Heng
Fu, Rui
Zhang, Shu-Sheng
Zhao, Qian
Feng, Chen-Guo
Lin, Guo-Qiang
A Zn-mediated propargylation/lactamization cascade reaction with chiral 2-formylbenzoate derived N-tert-butanesulfinyl imines was realized, which provided a practical and efficient method for the synthesis of chiral isoindolinones. High diastereoselectivities (up to 97:3 dr) and good reaction yields were observed for most examined cases.
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