Organic Letters p. 2939 - 2941 (2003)
Update date:2022-08-05
Topics:
Matsuya, Yuji
Kawaguchi, Takanori
Nemoto, Hideo
(Matrix presented) A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.
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(2003)Doi:10.1055/s-2003-41436
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(2001)Doi:10.1007/BF00946420
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