Formamidine as a versatile protecting group for primary amines: A mild procedure for hydrolytic removal

Article abstract of DOI:10.1080/00397919408010163

A mild, zinc chloride-promoted cleavage of N,N,-dimethyl-formamidine derivatives of primary amines to the free amines is described. Under slightly different hydrolytic conditions the corresponding N-formyl derivatives can be isolated.

Full text of DOI:10.1080/00397919408010163

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Formamidine as a Versatile
Protecting Group for Primary
Amines: A Mild Procedure for
Hydrolytic Removal
Dean Toste a , James McNulty a & Ian W. J. Still a
a J. Tuzo Wilson Research Laboratories, Erindale
College, University of Toronto in Mississauga,
Mississauga, Ontario, Canada, L5L 1C6
Version of record first published: 23 Sep 2006.
To cite this article: Dean Toste , James McNulty & Ian W. J. Still (1994): Formamidine
as a Versatile Protecting Group for Primary Amines: A Mild Procedure for
Hydrolytic Removal, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 24:11, 1617-1624
To link to this article: http://dx.doi.org/10.1080/00397919408010163
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