Bioorganic and Medicinal Chemistry Letters p. 1345 - 1348 (2003)
Update date:2022-08-04
Topics:
Chen, Ping
Norris, Derek
Haslow, Kristin D.
Dhar, T. G. Murali
Pitts, William J.
Watterson, Scott H.
Cheney, Daniel L.
Bassolino, Donna A.
Fleener, Catherine A.
Rouleau, Katherine A.
Hollenbaugh, Diane L.
Townsend, Robert M.
Barrish, Joel C.
Iwanowicz, Edwin J.
Screening of our in-house compound collection led to the discovery of 5-bromo-6-amino-2-isoquinoline 1 as a weak inhibitor of IMPDH. Subsequent optimization of 1 afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, represented by 17, with single-digit nanomolar potency against the enzyme.
View MoreGeen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Zibo Xiaoguang Chemical Material Co., Ltd
Contact:15954099116
Address:Boshan Development Zone
Hangzhou GreenCo Science & Technology Co., Ltd.
Contact:86-571-88257303
Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Zhejiang Linhai Xinhua Chemicals Factory
Contact:0086-13661858911
Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Doi:10.1021/ja01083a017
(1965)Doi:10.1016/j.tet.2010.01.099
(2010)Doi:10.1002/jps.2600820616
(1993)Doi:10.1039/c39860000012
(1986)Doi:10.1021/jo01298a042
(1980)Doi:10.1021/ja00522a059
(1980)