ISOLATION OF (10R,11R)-(+)-SQUALENE-10,11-EPOXIDE FROM THE RED ALGA LAURENCIA OKAMURAI AND ITS ENANTIOSELECTIVE SYNTHESIS

Article abstract of DOI:10.1016/S0040-4020(01)87533-5

(10R,11R)-(+)-Squalene-10,11-epoxide 1 has been isolated from the red alga Laurencia okamurai.On the basis of the spectral data and comparison to the racemic compound prepared from squalene, assigment of the planar structure was made.The enantioselective synthesis of 1 was performed, which determined the absolute stereochemistry of 1.