Journal of Medicinal Chemistry p. 412 - 417 (1979)
Update date:2022-08-02
Topics:
Ross
Harrison
Jolley
Neville
Todd
Verge
Dawson
Sweatman
The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.
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