Journal of Organic Chemistry p. 12301 - 12313 (2019)
Update date:2022-08-04
Topics:
Zou, Liang-Hua
Zhu, Hao
Zhu, Shuai
Shi, Kai
Yan, Cheng
Li, Ping-Gui
A copper-catalyzed protocol for the construction of various 2-aryl(alkyl)-3-acylquinolines or 3-arylquinolines using readily available anthranils and 1,3-diketones or aldehydes as starting materials is reported herein. Dioxygen as the sole oxidant and hexafluoroisopropanol as the solvent play an important role in both procedures. This ring-opening/reconstruction strategy involving N-O bond cleavage and C-N/C-C bond formation features high yields and broad substrate scope.
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