Organic Letters (2019)
Update date:2022-08-04
Topics: Derivatives Allylation Congeners Intramolecular Michael addition One-Pot Vinylogous Cascade Benzofuran
Harish, Battu
Subbireddy, Manyam
Obulesu, Owk
Suresh, Surisetti
A unique intramolecular vinylogous Michael addition leading to the synthesis of heterocycles has been disclosed. Base-promoted one-pot sequential O-allylation of o-hydroxy-cinnamates or -cinnamonitrile or -chalcones with γ-bromocrotonates followed by an intramolecular conjugate addition of vinylogous Michael donors resulted in the formation of highly substituted benzofuran derivatives in good to excellent yields. The intramolecular event followed by two [1,3]-H shifts leading to aromatization appears to be the key to the success of this unprecedented transformation.
View MoreShanghai Zhihua ChemTech Co., Ltd.
Contact:+86-13774313779
Address:Room 817 Suite B 3333 Shenjiang Road
Contact:021
Address:Pudong
Wuhan Chemchemical Co., Ltd.(expird)
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Contact:86 21 3772 9386
Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
Doi:10.1021/jo00870a004
(1976)Doi:10.1016/S0277-5387(03)00109-8
(2003)Doi:10.1039/b614294j
(2007)Doi:10.1002/ejoc.201200945
(2012)Doi:10.1007/BF00529573
(1992)Doi:10.1002/chem.201405197
(2015)