Journal of Medicinal Chemistry p. 472 - 475 (1976)
Update date:2022-08-04
Topics:
Biggs
Casy
Chu
Coutts
The preparation of three isomeric 1 tetralone hydrazones and three isomeric 1 indanone hydrazones possessing a single quaternary ammonium center is described. Several of the compounds possessed significant neuromuscular blocking activity, and two approached suxamethonium in potency. 1H NMR evidence obtained from a study of the N,N dimethylhydrazones indicated that the hydrazones adopted an E configuration in solution.
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