Bioorganic and Medicinal Chemistry Letters p. 2405 - 2408 (2003)
Update date:2022-08-03
Topics:
Misra, Raj N.
Xiao, Hai-Yun
Rawlins, David B.
Shan, Weifang
Kellar, Kristen A.
Mulheron, Janet G.
Sack, John S.
Tokarski, John S.
Kimball, S. David
Webster, Kevin R.
Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC50=6 nM, CDK2/cycE IC50=9 nM). The 2,6-difluorophenyl substitution was cri
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(2003)
