Antimalarial amino alcohols II: anthraceneaminoethanols and anthraceneaminopropanols (1 and 9 substituted)

Article abstract of DOI:10.1002/jps.2600641207

The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1 aminoethanols, two 9 aminoethanols, and two 9 aminopropanols, prepared from substituted anthraquinones or from 10 chloro 9 anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure activity relationships, is discussed in the light of previously published work.