Analogues of S adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5' thioether linkage

Article abstract of DOI:10.1021/jm00227a021

The synthesis of S adenosylhomocysteine analogues, in which the 5' thioether linkage is replaced by an oxygen or nitrogen isostere, has been investigated. These compounds were designed to be resistant to enzyme catalyzed hydrolytic cleavage of the 5' subs