Archiv der Pharmazie p. 233 - 234 (1997)
Update date:2022-08-05
Topics: Synthesis NMR spectroscopy Mass spectrometry Reaction Conditions In vitro assay Bone resorption
Pifferi, Giorgio
Da Re, Paolo
Valenti, Piero
Bisi, Alessandra
Malandrino, Salvatore
A topological modification of ipriflavone 1, a recent antiosteoporotic drug, is described, The flavone moiety of 1 has been replaced by a xanthone one, Among the new derivatives, the 3,6-diisopropoxyxanthone (2a) has shown significant bone resorption inhibition in in vitro and in vivo tests.
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Doi:10.1002/jps.2600650319
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