An efficient synthesis of S-(+)-amphetamine

Article abstract of DOI:10.1016/S0957-4166(00)80369-9

Optically active (S)-(+)-amphetamine hydrochloride (5-HCl) was prepared from (1S,2S)-2-amino-1-phenyl-1,3-propanediol (1) via its 3-iodo intermediate (3). A phthaloyl group was used for protecting the amine function.