Synthesis of Azole Nucleoside 5′-Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases

DOI: 10.1081/NCN-120027838

Source and publish data:

Nucleosides, nucleotides and nucleic acids p. 317 - 337 (2004)

Update date:2022-08-05

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Authors:

Wang, Guangyi

Sakthivel, Kandasamy

Rajappan, Vasanthakumar

Bruice, Thomas W.

Tucker, Kathleen

Fagan, Patrick

Brooks, Jennifer L.

Hurd, Tiffany

Leeds, Janet M.

Cook, P. Dan

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Article abstract of DOI:10.1081/NCN-120027838

IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not ass

Full text of DOI:10.1081/NCN-120027838

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