Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge 5. A highly concise and efficient synthesis of the C37～C54 tricyclic JKL-ring part

Article abstract of DOI:10.3987/COM-95-S30

A concise and efficient synthesis of C₃₇～C₅₄ tricyclic JKL-ring unit (2) of halichondrin B (1) utilizing C₂-symmetric spiroketal derivative (5) as a synthetic key intermediate, easily provided from dimethyl L-(+)-tartrate,