Facile and Practical Total Syntheses of (+/-)-Mukulol and (+/-)-Cembrene by Low-valent Titanium-induced Keto Ester Cyclization

Article abstract of DOI:10.1246/cl.1994.741

A direct approach of low-valent titanium-induced intramolecular keto ester cyclization was first applied to the total syntheses of macrocyclic diterpenoids, by which (+/-)-mukulol and (+/-)-cembrene were synthesized from geranylacetone by a short and efficient route.