Concise and enantioselective synthesis of Fmoc-Pmp(But) 2-OH and design of potent Pmp-containing Grb2-SH2 domain antagonists

DOI: 10.1021/ol035078+

Source and publish data:

Organic Letters p. 3095 - 3098 (2003)

Update date:2022-08-04

Topics:

Authors:

Li, Peng

Zhang, Manchao

Peach, Megan L.

Liu, Hongpeng

Yang, Dajun

Roller, Peter P.

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Article abstract of DOI:10.1021/ol035078+

(Matrix presented) L-Phosphonomethylphenylalanine (L-Pmp) is an important phosphatase-resistant pTyr analogue. A most concise and stereoselective approach to the synthesis of the suitably protected Fmoc-Pmp(Bu ^t)₂-OH was developed in

Full text of DOI:10.1021/ol035078+

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