
Chemical and Pharmaceutical Bulletin p. 4396 - 4401 (1984)
Update date:2022-08-04
Topics:
Shimada
Ohishi
Nambara
The occurrence of new bufotoxins, in which L-histidine, L-3-methylhistidine, or L-1-methylhistidine replaces the arginine residue of hitherto known 'bufotoxin', in the skin of the Formosan toad, Bufo melanostrictus SCHNEIDER, is reported. Five novel bufotoxins, bufotalin 3-suberoyl-L-histidine, -3-methylhistidine and -1-methylhistidine esters and 19-hydroxybufalin 3-suberoyl-L-histidine and -3-methylhistidine esters, were separated by usual chromatographic methods including reversed phase high-performance liquid chromatography, and their structures were elucidated by degradative and synthetic means.
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Doi:10.1016/S0008-6215(00)83716-7
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(1980)Doi:10.1055/s-2003-37506
(2003)