Stereoselective synthesis of α,β-unsaturated carboxylic acids from alkynes using the Fe(CO)5/t-BuOK/AcOH/CH2Cl 2 reagent system

Article abstract of DOI:10.1016/j.jorganchem.2012.01.005

Reactive iron carbonyl species generated in situ using the Fe(CO) ₅/t-BuOK/CH₃COOH/CH₂Cl₂ reagent system reacts with alkynes to give the corresponding α,β-unsaturated carboxylic acids after CuCl₂·2H₂O oxidation with some regio and stereoselectivity.