Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

DOI: 10.1016/j.bmcl.2003.08.005

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3719 - 3720 (2003)

Update date:2022-08-03

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Authors:

Reddy, Y. Krishna

Reddy, L. Manmohan

Capdevila, Jorge H.

Falck Falck

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Article abstract of DOI:10.1016/j.bmcl.2003.08.005

An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.

Full text of DOI:10.1016/j.bmcl.2003.08.005

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