Angewandte Chemie - International Edition p. 4657 - 4660 (2003)
Update date:2022-08-02
Topics:
Ritter, Thomas K.
Mong, Kwok-Kong T.
Liu, Haitian
Nakatani, Takuji
Wong, Chi-Huey
The notoriously difficult glycosylation of vancomycin was tackled in a one-pot procedure. A number of oligosaccharides were synthesized and attached to the vancomycin aglycon to create a library of derivatives (see formula) to probe the effect of glycosylation on the antibiotic activity.
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