Synthesis of some piperazinylpyrazolo[3,4-b]pyridines as selective serotonin re-uptake inhibitors

Article abstract of DOI:10.1002/jhet.5570340314

A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-position showed activity as selective serotonin re-uptake inhibitors.