Journal of Heterocyclic Chemistry p. 789 - 795 (1997)
Update date:2022-08-04
Topics:
Shutske, Gregory M.
Roehr, Joachim E.
A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-position showed activity as selective serotonin re-uptake inhibitors.
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