Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis

DOI: 10.1016/S0968-0896(03)00191-3

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3205 - 3214 (2003)

Update date:2022-08-05

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Authors:

Dardonville, Christophe

Rinaldi, Eliana

Hanau, Stefania

Barrett, Michael P.

Brun, Reto

Gilbert, Ian H.

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Article abstract of DOI:10.1016/S0968-0896(03)00191-3

The synthesis and biological evaluation of three series of 6-phosphogluconate (6PG) analogues is described. (2R)-2-Methyl-4,5-dideoxy, (2R)-2-methyl-4-deoxy and 2,4-dideoxy analogues of 6PG were tested as inhibitors of 6-phosphogluconate dehydrogenase (6P

Full text of DOI:10.1016/S0968-0896(03)00191-3

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